Our published work has over 1,900 citations.

Published Work supporting our Cytesia Platform

Cytesia is built on a number of fundamental discoveries which are summarized in our published works below.

  1. Platelets actively sequester angiogenesis regulators. Klement GL, Yip TT, Cassiola F, Kikuchi L, Cervi D, Podust V, Italiano JE, Wheatley E, Abou-Slaybi A, Bender E, Almog N, Kieran MW, Folkman J. Blood. 2009 Mar 19;113(12):2835-42. doi: 10.1182/blood-2008-06-159541. Epub 2008 Nov 25. PMID: 190367022 Cited by 309
  2. Platelet-associated PF-4 as a biomarker of early tumor growth. Cervi D, Yip TT, Bhattacharya N, Podust VN, Peterson J, Abou-Slaybi A, Naumov GN, Bender E, Almog N, Italiano JE Jr, Folkman J, Klement GL. Blood. 2008 Feb 1;111(3):1201-7. Epub 2007 Oct PMID: 17914028 Cited by 143
  3. Angiogenesis is regulated by a novel mechanism: pro- and antiangiogenic proteins are organized into separate platelet alpha granules and differentially released. Italiano JE Jr, Richardson JL, Patel-Hett S, Battinelli E, Zaslavsky A, Short S, Ryeom S, Folkman J, Klement GL. Blood. 2008 Feb 1;111(3):1227-33. Epub 2007 Oct 25. PMID: 17962514 Cited by 840
  4. Tumors stimulate platelet delivery of angiogenic factors in vivo: an unexpected benefit. Pietramaggiori G, Scherer SS, Cervi D, Klement G, Orgill DP. American Journal of Pathology. 2008 Dec;173(6):1609-16. doi: 10.2353/ajpath.2008.080474. Epub 2008 Nov 6. Cited by 48
  5. The Role of Platelets in Angiogenesis. Klement, Giannoula & Shai, Ela & Varon, David. (2013).  Platelets. 487-502. 10.1016/B978-0-12-387837-3.00024-9.
  6. Cell therapy, a new standard in management of chronic critical limb ischemia and foot ulcer. Procházka V, Gumulec J, Jalůvka F, Salounová D, Jonszta T, Czerný D, Krajča J, Urbanec R, Klement P, Martinek J, Klement GL. Cell Transplant. 2010;19(11):1413-24. doi: 10.3727/096368910X514170. Epub 2010 Jun 7. PMID: 20529449 Cited by 145
  7. VEGF, PF4 and PDGF are elevated in platelets of colorectal cancer patients. Angiogenesis volume 15, pages265–273(2012) Jon E. Peterson, David Zurakowski, Joseph E. Italiano Jr, Lea V. Michel, Susan Connors, Marsha Oenick, Robert J. D’Amato, Giannoula L. Klement & Judah Folkman Cited by 179
  8. Normal ranges of angiogenesis regulatory proteins in human platelets. Jon E. Peterson  David Zurakowski  Joseph E. Italiano Jr.  Lea V. Michel  Lucius Fox  Giannoula L. Klement  Judah Folkman First published: 23 June 2010 Cited by 152
  9. Hyperthermia inhibits platelet hemostatic functions and selectively regulates the release of alpha-granule proteins. Etulain J, Lapponi MJ, Patrucchi SJ, Romaniuk MA, Benzadón R, Klement GL, Negrotto S, Schattner M. J Thromb Haemost. 2011 Aug;9(8):1562-71. doi: 10.1111/j.1538-7836.2011.04394.x. PMID: 21649851 Cited by 36
  10. Platelet Biomarkers in Tumor Growth. Klement, Giannoula. (2011). Current Proteomics. 8. 169-180. 10.2174/157016411797247486. Cited by 2
  11. Acidosis downregulates platelet haemostatic functions and promotes neutrophil proinflammatory responses mediated by platelets. Etulain J, Negrotto S, Carestia A, Pozner RG, Romaniuk MA, D’Atri LP, Klement GL, Schattner M. Thromb Haemost. 2012 Jan;107(1):99-110. doi: 10.1160/TH11-06-0443. Epub 2011 Dec 8. PMID: 22159527 Cited by 61
  12. Isolation and proteomic analysis of platelets by SELDI-TOF MS. Downing SR, Klement GL. Methods Mol Biol. 2012;818:153-70. doi: 10.1007/978-1-61779-418-6_12. PMID: 22083823 Cited by 8
  13. Platelet proteome and tumor dormancy: can platelets content serve as predictive biomarkers for exit of tumors from dormancy? Almog N, Klement GL. Cancers (Basel). 2010 May 11;2(2):842-58. doi: 10.3390/cancers2020842. PMID: 24281097 Cited by 16

Published work supporting our therapy design strategies

The fundamental discoveries which under pin the Aiomic target selection platform are outlined in our published work referenced below.

  1. Thermodynamics and Cancer Dormancy: A Perspective, EA Rietman, JA Tuszynski, Tumor Dormancy and Recurrence, 61-79, 2017
  2. Personalized anticancer therapy selection using molecular landscape topology and thermodynamics, EA Rietman, JG Scott, JA Tuszynski, GL Klement, Oncotarget 8 (12), 18735, 2017
  3. Thermodynamic measures of cancer: Gibbs free energy and entropy of protein–protein interactions. EA Rietman, J Platig, JA Tuszynski, GL Klement, Journal of biological physics 42 (3), 339-350, 2016
  4. Future paradigms for precision oncology. GL Klement, K Arkun, D Valik, T Roffidal, A Hashemi, C Klement, et al, Oncotarget 7 (29), 46813-11, 2016
  5. Eco-evolution of cancer resistance (2016)
  6. Design principles for cancer therapy guided by changes in complexity of protein-protein interaction networks, S Benzekry, JA Tuszynski, EA Rietman, GL Klement. Biology direct 10 (1), 32-12, 2015
  7. Molecular Signaling Network Complexity Is Correlated with Cancer Patient Survivability, D.Breitkreutz, L. Hlatky, E. A. Rietman, and J. A. Tuszynski,  Proceedings of the National Academy of Sciences of the USA, Jun 5;109(23):9209-12. Epub 2012 (2012)
  8. Gibbs Free Energy of Protein-Protein Interactions Correlates with ATP Production in Cancer Cells SM Golas, AN Nguyen, EA Rietman, Jack A Tuszynski, bioRxiv, 498121, 2018. Doi:
  9. Gibbs free energy of protein-protein interactions reflects tumor stage. E Rietman, A Bloemendal, J Platig, J Tuszynski, GL Klement, BioRxiv, 022491-3, 2015
  10. Algebraic and topological indices of molecular pathway networks in human cancers. P Hinow, EA Rietman, JA Tuszynski, arXiv preprint arXiv:1405.1462 9, 2014
  11. Personalized Therapy Design for Systemic Lupus Erythematosus Based on the Analysis of Protein-Protein Interaction Networks. 24 Feb 2019. Elizabeth J Brant, Edward A Rietman, Giannoula Lakka-Klement, Marco Cavaglia, Jack A. Tusznski. Doi:
  12. Gibbs Free Energy, a thermodynamic measure of protein-protein interactions, correlates with neurologic disability. 22 Jan 2019. Michael Keegan, Hava T Siegelmann, Edward A Rietman, Giannola Lakka Klement. doi: